Invention Grant
US07670806B2 ADP-ribosyl acceptor hydrolase 3 (ARH3) polypeptides and methods of use
有权
ADP-核糖基受体水解酶3（ARH3）多肽及其使用方法
- Patent Title: ADP-ribosyl acceptor hydrolase 3 (ARH3) polypeptides and methods of use
- Patent Title (中): ADP-核糖基受体水解酶3（ARH3）多肽及其使用方法
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Application No.: US12047185Application Date: 2008-03-12
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Publication No.: US07670806B2Publication Date: 2010-03-02
- Inventor: Joel Moss , Shunya Oka , Jiro Kato , Jianfeng Zhu , Atsushi Kasamatsu
- Applicant: Joel Moss , Shunya Oka , Jiro Kato , Jianfeng Zhu , Atsushi Kasamatsu
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: C12P19/00
- IPC: C12P19/00 ; C12N9/00 ; C12N1/20 ; C12N15/00 ; C07H21/04
Abstract:
This disclosure provides methods for catalyzing the release of ADP-ribose from poly(ADP-ribose) or O-acetyl-ADP-ribose. Also provided are methods for modifying DNA repair or chromatin structure by introducing into the cell an agent that modifies the activity of an ARH3 polypeptide, or variant or fragment thereof. Further provided are methods for screening molecules involved in the poly(ADP-ribosyl)ation of proteins or O-acetyl-ADP-ribose content, and method for treating disorders by altering activity of an ARH3 protein.
Public/Granted literature
- US20080207555A1 HYDROLASE AND METHODS FOR ITS USE Public/Granted day:2008-08-28
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