Invention Grant
US07671036B2 Positively-charged peptide nucleic acid analogs with improved properties
失效
具有改进性能的带正电荷的肽核酸类似物
- Patent Title: Positively-charged peptide nucleic acid analogs with improved properties
- Patent Title (中): 具有改进性能的带正电荷的肽核酸类似物
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Application No.: US10297788Application Date: 2001-06-22
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Publication No.: US07671036B2Publication Date: 2010-03-02
- Inventor: Jehoshua Katzhendler , Ada Schlossman , Yousuf Najajreh , Dan Gibson
- Applicant: Jehoshua Katzhendler , Ada Schlossman , Yousuf Najajreh , Dan Gibson
- Applicant Address: IL Jerusalem
- Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem
- Current Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem
- Current Assignee Address: IL Jerusalem
- Agency: Cooper & Dunham LLP
- Agent John P. White
- International Application: PCT/IL01/00570 WO 20010622
- International Announcement: WO01/98522 WO 20011227
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; A01N43/90 ; C07D473/00
Abstract:
The present invention relates to novel types of peptide nucleic acids (PNAS) with improved properties. In particular, it relates to positively charged PNA units having an ethylene linker between the backbone and the nucleobase, to oligonucleotide analogs comprising these units, to oligomers comprising these units, and to the use of positively charged PNAs as novel delivery agents with therapeutic and diagnostic applications including for antisense therapy.
Public/Granted literature
- US20040034043A1 Positively-charged peptide nucleic acid analogs with improved properties Public/Granted day:2004-02-19
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