Invention Grant
- Patent Title: Pyrrole based inhibitors of glycogen synthase kinase 3
- Patent Title (中): 基于吡咯的糖原合酶激酶抑制剂3
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Application No.: US11761937Application Date: 2007-06-12
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Publication No.: US07671049B2Publication Date: 2010-03-02
- Inventor: Manoj C. Desai , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Savithri Ramurthy , Sharadha Subramanian , Allan S. Wagman
- Applicant: Manoj C. Desai , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Savithri Ramurthy , Sharadha Subramanian , Allan S. Wagman
- Applicant Address: US CA Emeryville
- Assignee: Novartis Vaccines and Diagnostics, Inc.
- Current Assignee: Novartis Vaccines and Diagnostics, Inc.
- Current Assignee Address: US CA Emeryville
- Agent Vinit Kathardekar
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/445 ; A61K31/497
Abstract:
New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
Public/Granted literature
- US20070244109A1 PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 Public/Granted day:2007-10-18
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