Invention Grant
- Patent Title: Benzamide inhibitors of the P2X7 receptor
- Patent Title (中): P2X7受体的苯甲酰胺抑制剂
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Application No.: US12147212Application Date: 2008-06-26
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Publication No.: US07671053B2Publication Date: 2010-03-02
- Inventor: Mark A. Dombrowski , Allen J. Duplantier
- Applicant: Mark A. Dombrowski , Allen J. Duplantier
- Applicant Address: US NY New York
- Assignee: Pfizer, Inc.
- Current Assignee: Pfizer, Inc.
- Current Assignee Address: US NY New York
- Agency: Pfizer, Inc.
- Agent Julie M. Lappin
- Main IPC: C07D253/075
- IPC: C07D253/075 ; A61K31/53 ; A61P11/06
Abstract:
The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1-R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
Public/Granted literature
- US20090042886A1 Benzamide Inhibitors of the P2X7 Receptor Public/Granted day:2009-02-12
Information query
