Invention Grant
US07671069B2 Tricyclic, heteroaromatic compounds modulating CXCR4 and/ or CXCR7
有权
调节CXCR4和/或CXCR7的三环杂芳香化合物
- Patent Title: Tricyclic, heteroaromatic compounds modulating CXCR4 and/ or CXCR7
- Patent Title (中): 调节CXCR4和/或CXCR7的三环杂芳香化合物
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Application No.: US11694935Application Date: 2007-03-30
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Publication No.: US07671069B2Publication Date: 2010-03-02
- Inventor: Manmohan Reddy Leleti , William D. Thomas , Penglie Zhang , Andrew M. K. Pennell
- Applicant: Manmohan Reddy Leleti , William D. Thomas , Penglie Zhang , Andrew M. K. Pennell
- Applicant Address: US CA Mountain View
- Assignee: ChemoCentryx, Inc.
- Current Assignee: ChemoCentryx, Inc.
- Current Assignee Address: US CA Mountain View
- Agency: Townsend and Townsend and Crew LLP
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D471/04
Abstract:
The present invention is directed to novel compounds and pharmaceutical compositions that inhibit the binding of the SDF-1 chemokine to the chemokine receptor CXCR4 and/or the binding of the SDF-1 or I-TAC chemokines to the chemokine receptor CCXCKR2 (CXCR7). These compounds are useful in preventing tumor cell proliferation, tumor formation, metastasis, inflammatory diseases, treatment of HIV infectivity, treatment of stem cell differentiation and mobilization disorders, and ocular disorders.
Public/Granted literature
- US20070254915A1 CXCR4 MODULATORS Public/Granted day:2007-11-01
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