Invention Grant
US07671073B2 Cyclohexylalanine derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
有权
环己基丙氨酸衍生物作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
- Patent Title: Cyclohexylalanine derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
- Patent Title (中): 环己基丙氨酸衍生物作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
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Application No.: US11579265Application Date: 2005-05-13
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Publication No.: US07671073B2Publication Date: 2010-03-02
- Inventor: Joseph L. Duffy , David E. Kaelin, Jr. , Ann E. Weber , Brian A Kirk
- Applicant: Joseph L. Duffy , David E. Kaelin, Jr. , Ann E. Weber , Brian A Kirk
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Philippe L. Durette; Catherine D. Fitch
- International Application: PCT/US2005/016825 WO 20050513
- International Announcement: WO2005/116029 WO 20051208
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/41 ; A61K31/42 ; A61K31/415 ; A61K31/40 ; C07D401/10 ; C07D271/06 ; C07D263/24 ; C07D249/16
Abstract:
The present invention is directed to novel cyclohexylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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