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US07671203B2 Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography 失效
使用反相制备色谱法分离和纯化至少一种麻醉生物碱的方法和系统

  • Patent Title: Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography
  • Patent Title (中): 使用反相制备色谱法分离和纯化至少一种麻醉生物碱的方法和系统
  • Application No.: US10501353
    Application Date: 2003-02-18
  • Publication No.: US07671203B2
    Publication Date: 2010-03-02
  • Inventor: Enrico Anthony Antonini
  • Applicant: Enrico Anthony Antonini
  • Applicant Address: US MO Hazelwood
  • Assignee: Mallinckrodt Inc.
  • Current Assignee: Mallinckrodt Inc.
  • Current Assignee Address: US MO Hazelwood
  • International Application: PCT/US03/04498 WO 20030218
  • International Announcement: WO03/074526 WO 20030912
  • Main IPC: C07D489/02
  • IPC: C07D489/02
Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography
Abstract:
An apparatus and method for separating at least one narcotic alkaloid that includes loading a stationary phase media into a high performance preparative liquid chromatography column, feeding a crude narcotic alkaloid solution into the chromatographic column, applying a mobile phase to the chromatographic column, and recovering a narcotic alkaloid eluate from the chromatographic column. The narcotic eluates arc collected and treated separately from each other. Each separated alkaloid, however, has sufficient recovery and purity.
Abstract(Chinese):

一种用于分离至少一种麻醉生物碱的装置和方法，其包括将固定相介质加载到高性能制备液相色谱柱中，将粗制麻醉生物碱溶液进料到色谱柱中，将流动相加到色谱柱中，并回收 来自色谱柱的麻醉生物碱洗脱液。 麻醉洗脱液彼此分开收集和处理。 然而，每种分离的生物碱具有足够的回收和纯度。

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