A method of manufacturing at least one device defining a volume for retaining fluid or sensitive material capable of changing physical properties, particularly optical properties, via application of voltage, or electrical properties via stress or radiation, the device including a first front substrate and a second back substrate maintained at a constant distance from each other, and joined by a sealing joint which defines the volume, wherein the method includes the steps of: structuring at least one wall, which defines, via its inner lateral face, the volume for retaining the sensitive medium or fluid, on one of the substrates; joining the second substrate to the first substrate; introducing a sealing material into a gap defined by the outer lateral face of the wall and the two superposed substrates until at least part of the gap is occupied by sealing material, and solidifying the sealing material to form the sealing frame.