A surgical instrument comprising an instrument handle linked to a proximal end portion of a tube shaft to the distal end portion of which an instrument head is linked so as to be inclinable, in which instrument head, in turn, an effector including at least one pivotable engaging element is rotatably supported. The instrument handle comprises a number of manipulators and/or operating mechanisms designed for operating the instrument head and/or the effector. One of the manipulators consists of an operating element in the form of a rotary knob with respect to its function, the operating element being rotatably supported on the instrument handle.