Invention Grant
- Patent Title: Enzyme-prodrug therapy for prosthetic joint repair
- Patent Title (中): 用于假体关节修复的酶前药治疗
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Application No.: US11072980Application Date: 2005-03-04
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Publication No.: US07674454B2Publication Date: 2010-03-09
- Inventor: Tom J. W. Huizinga , Robert C. Hoeben , Rob G. H. H. Nelissen , Andrew Mountain
- Applicant: Tom J. W. Huizinga , Robert C. Hoeben , Rob G. H. H. Nelissen , Andrew Mountain
- Applicant Address: GB NL
- Assignee: Innovata Limited,Academisch Ziekenhuis Leiden
- Current Assignee: Innovata Limited,Academisch Ziekenhuis Leiden
- Current Assignee Address: GB NL
- Agent Cozen O'Connor
- Priority: GB0405103.3 20040306; GB0420217.2 20040911
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K31/70 ; C12N15/63
Abstract:
The invention relates to the use of gene therapy in the treatment of aseptic loosening of orthopaedic prostheses and discloses methods of refixing such prostheses without open revision surgery. In particular, it provides adenoviral vectors and prodrugs for simultaneous, separate or sequential use in the destruction of interface tissue allowing subsequent recementing of loose prostheses in a minimally invasive manner.
Public/Granted literature
- US20050260160A1 Enzyme-prodrug therapy for prosthetic joint repair Public/Granted day:2005-11-24
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