Invention Grant
- Patent Title: Methods for enhancing neuroprotection via administration of stem cells and blood brain barrier permeabilizers
- Patent Title (中): 通过施用干细胞和血脑屏障渗透剂增强神经保护作用的方法
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Application No.: US11012849Application Date: 2004-12-15
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Publication No.: US07674457B2Publication Date: 2010-03-09
- Inventor: Cesario V Borlongan , Paul R. Sanberg
- Applicant: Cesario V Borlongan , Paul R. Sanberg
- Applicant Address: US FL Tampa
- Assignee: University of South Florida
- Current Assignee: University of South Florida
- Current Assignee Address: US FL Tampa
- Agency: Smith & Hopen, P.A.
- Agent Robert Varkonyi
- Main IPC: A61K35/14
- IPC: A61K35/14 ; A61K31/047
Abstract:
The present invention provides compositions and methods for enhancing the neuroprotective effect of umbilical cord blood cells. More particularly, the present invention provides methods of treating neurodegenerative disorders by administering umbilical cord blood cells and a substance capable of permeabilizing the blood brain barrier. In one embodiment, the blood brain barrier permeabilizer is mannitol. In another embodiment, the blood brain barrier permeabilizer is Cereport.
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