Invention Grant
- Patent Title: Targeting and prolonging association of drugs to the luminal surface of the pulmonary vascular endothelial cells using antibodies that bind to ICAM-1
- Patent Title (中): 使用结合ICAM-1的抗体靶向和延长药物与肺血管内皮细胞的腔表面的关联
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Application No.: US11234594Application Date: 2005-09-23
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Publication No.: US07674466B2Publication Date: 2010-03-09
- Inventor: Vladimir R. Muzykantov , Juan Carlos Murciano , D. Neil Granger
- Applicant: Vladimir R. Muzykantov , Juan Carlos Murciano , D. Neil Granger
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Howson & Howson LLP
- Main IPC: A61K39/00
- IPC: A61K39/00
Abstract:
Methods for targeting and prolonging association of a selected drug to the luminal surface of pulmonary vascular endothelium of an animal are provided wherein a selected drug is administered to an animal in combination with a non-internalizable ICAM-1 antibody which binds to an antigen on the luminal surface of the pulmonary vasculature. This method is particularly useful in dissolution of fibrin clots or prevention of the intravascular coagulation in the pulmonary vasculature.
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