Invention Grant
- Patent Title: Transfected cell line and a method using the same for the high throughput screening for inhibitors of the T-type calcium channel alpha-1H
- Patent Title (中): 转染细胞系和使用该方法用于高通量筛选T型钙通道α-1H抑制剂的方法
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Application No.: US11162487Application Date: 2005-09-12
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Publication No.: US07674596B2Publication Date: 2010-03-09
- Inventor: Seong-Woo Jeong , Jung-Ha Lee , Byong-Gon Park , Edward Perez-Reyes , Dong Jin Kim , Hee Sup Shin , Taehyun Kim , Hyewhon Rhim
- Applicant: Seong-Woo Jeong , Jung-Ha Lee , Byong-Gon Park , Edward Perez-Reyes , Dong Jin Kim , Hee Sup Shin , Taehyun Kim , Hyewhon Rhim
- Applicant Address: KR Seoul
- Assignee: Korea Institute of Science and Technology
- Current Assignee: Korea Institute of Science and Technology
- Current Assignee Address: KR Seoul
- Agency: JHK Law
- Agent Joseph Hyosuk Kim
- Priority: KR10-2005-0016221 20050226
- Main IPC: C12N5/10
- IPC: C12N5/10 ; G01N33/53
Abstract:
The present invention relates to a cell line in which a potassium channel is introduced. More specifically, it is a cell line capable of activating the T-type α1H calcium channel by depolarization wherein a vector encoding a potassium channel is introduced. Since the cell line of the present invention is available for a high throughput screening of candidate T-type α1H calcium channel inhibitors, it may accelerate the development of therapeutic agents for diseases related to T-type α1H calcium channels.
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