Invention Grant
US07674605B2 Antibodies recognizing a carbohydrate containing epitope on CD-43 and CEA expressed on cancer cells and methods using same
有权
识别在癌细胞上表达的CD-43和CEA上的含碳水化合物表位的抗体及使用其的方法
- Patent Title: Antibodies recognizing a carbohydrate containing epitope on CD-43 and CEA expressed on cancer cells and methods using same
- Patent Title (中): 识别在癌细胞上表达的CD-43和CEA上的含碳水化合物表位的抗体及使用其的方法
-
Application No.: US11811303Application Date: 2007-06-07
-
Publication No.: US07674605B2Publication Date: 2010-03-09
- Inventor: Rong-Hwa Lin , Leewen Lin , Shih-Yao Lin , Shu-Hua Lee
- Applicant: Rong-Hwa Lin , Leewen Lin , Shih-Yao Lin , Shu-Hua Lee
- Applicant Address: NL
- Assignee: BioAlliance C.V.
- Current Assignee: BioAlliance C.V.
- Current Assignee Address: NL
- Agency: Morrison & Foerster LLP
- Main IPC: C12P21/08
- IPC: C12P21/08
Abstract:
The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not specifically bind to a CD43 expressed by a leukocyte or by a Jurkat cell, and is capable of inducing apoptosis of the nonhematopoietic cancer cell after binding to the epitope on cell surface of the nonhematopoietic cancer cell in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate structure and the binding of the antibody to the epitope is inhibited by a carbohydrate comprising a Lea structure, a Lea-lactose structure, a LNDFH II structure, or a LNT structure. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes.
Public/Granted literature
Information query
