Invention Grant
- Patent Title: Processes for preparing eptifibatide
- Patent Title (中): 制备埃替非巴肽的方法
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Application No.: US11101983Application Date: 2005-04-08
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Publication No.: US07674768B2Publication Date: 2010-03-09
- Inventor: Guojie Ho , Antoinette D. Paone , Luciano Forni , Catherine De Tollenaere , Brice Bonnet , Christine Devijver
- Applicant: Guojie Ho , Antoinette D. Paone , Luciano Forni , Catherine De Tollenaere , Brice Bonnet , Christine Devijver
- Applicant Address: US MA Cambridge
- Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Thomas A. Wootton; Noel E. Day
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K16/00
Abstract:
The present invention provides, inter alia, convergent processes for preparing eptifibatide that involve coupling a 2-6 eptifibatide fragment to an activated cysteinamide residue to form a 2-7 eptifibatide fragment, attaching a mercaptopropionic acid residue to the 2-7 eptifibatide fragment through disulfide bond formation, coupling the peptide intramolecularly, and removing the protecting group, to form eptifibatide. The invention further provides products produced by the described processes, novel compounds that can be used as synthetic intermediates for the preparation of eptifibatide, and novel compounds that are structurally similar to eptifibatide.
Public/Granted literature
- US20060036071A1 Processes for preparing eptifibatide Public/Granted day:2006-02-16
Information query
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