Invention Grant
- Patent Title: Neutralizing antibodies and methods of use thereof
- Patent Title (中): 中和抗体及其使用方法
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Application No.: US11151916Application Date: 2005-06-14
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Publication No.: US07674884B2Publication Date: 2010-03-09
- Inventor: Greg Elson , Olivier Leger
- Applicant: Greg Elson , Olivier Leger
- Applicant Address: CH Geneva
- Assignee: Novimmune S.A.
- Current Assignee: Novimmune S.A.
- Current Assignee Address: CH Geneva
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Agent Ivor R. Elrifi
- Main IPC: C12P21/08
- IPC: C12P21/08 ; C07K16/00 ; A61K39/395 ; A61K39/00
Abstract:
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not complexed with MD-2. The invention further provides methods of using the humanized monoclonal antibodies as therapeutics. This invention also provides soluble chimeric proteins, methods of expressing and purifying soluble chimeric proteins, and methods of using soluble chimeric proteins as therapeutics, in screening assays and in the production of antibodies.
Public/Granted literature
- US20080050366A1 Neutralizing antibodies and methods of use thereof Public/Granted day:2008-02-28
Information query
