The present invention relates to methods for space-time coding and decoding in a wireless communication system with multiple antennas including: generating an orthogonal matrix according to signals to be transmitted; generating a coefficient matrix corresponding to the orthogonal matrix according to channel status information received; and generating a transmission matrix according to the orthogonal matrix and the coefficient matrix; performing a weight-combination for received signals according to channel status information in a receiver; and obtaining estimations of transmitted signals corresponding to the received signals by performing detection for the received signals. The present invention also provides apparatuses for space-time coding and decoding. By applying the present invention, the bit error rate of a system is reduced and bit error performance of the system is improved. And the transmission rate of the system is increased remarkably when there are more than one complex signals to be transmitted.