A bellows-based patient breath-hold monitoring and feedback system for use in intermittent mode CT fluoroscopy-guided biopsies of the lung or upper abdomen where respiratory motion is a problem. Breath-hold monitoring and feedback with the bellows system allows a patient to perform consistent breath-holds at a preselected level, which in turn, optimizes intermittent mode CT fluoroscopy-guided biopsies of the lung or upper abdomen by allowing target lesions to be reliably visualized.