Invention Grant
US07678374B2 Viral vectors expressing fusion of viral large envelope protein and protein of interest
有权
病毒载体表达病毒大包络蛋白和感兴趣的蛋白质的融合
- Patent Title: Viral vectors expressing fusion of viral large envelope protein and protein of interest
- Patent Title (中): 病毒载体表达病毒大包络蛋白和感兴趣的蛋白质的融合
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Application No.: US10553683Application Date: 2004-04-16
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Publication No.: US07678374B2Publication Date: 2010-03-16
- Inventor: David Andrew Anderson , Elizabeth Vera Ludmila Grgacic
- Applicant: David Andrew Anderson , Elizabeth Vera Ludmila Grgacic
- Applicant Address: AU Armadale, Victoria
- Assignee: Hepgenics Pty Ltd
- Current Assignee: Hepgenics Pty Ltd
- Current Assignee Address: AU Armadale, Victoria
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: AU2003901876 20030417
- International Application: PCT/AU2004/000511 WO 20040416
- International Announcement: WO2004/092387 WO 20041028
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K14/00
Abstract:
The present invention provides a virus-like particle (VLP) comprising i) a polypeptide comprising a polypeptide of interest (POI) and at least a particle-associating portion of a large envelope (L) polypeptide of an avian hepadnavirus or a functional derivative or homolog thereof, and ii) a small envelope (S) polypeptide of an avian hepadnavirus or a functional derivative or homolog thereof. By introducing one or more POIs into the L polypeptide, the POI is translocated along with L into a particle structure made up primarily of S polypeptide. The present invention furthermore provides methods for producing a recombinant virus-like particle.
Public/Granted literature
- US20070099262A1 Viral vectors expressing fusion of viral large envelope protein and protein of interest Public/Granted day:2007-05-03
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