A heat-sensitive lithographic printing plate precursor is disclosed which comprises a support having a hydrophilic surface and a coating which does not dissolve in an aqueous alkaline developer in the unexposed areas and which becomes soluble in an aqueous alkaline developer in the exposed areas, and an intermediate layer between said hydrophilic surface or said hydrophilic layer and said coating, wherein the intermediate layer comprises a first polymer having a first monomeric unit of formula I wherein R1, R2 and R3 are independently a hydrogen atom or an optionally substituted alkyl group, R4 and R5 are independently an optionally substituted alkyl, cycloalkyl, aryl or arylalkyl group. The precursor exhibits an excellent differentiation in dissolution kinetics between the exposed and non-exposed areas of the coating and a high chemical resistance against printing liquids and press chemicals.