Invention Grant
- Patent Title: Nucleic acid shuffling
- Patent Title (中): 核酸洗牌
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Application No.: US10101461Application Date: 2002-03-19
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Publication No.: US07678554B2Publication Date: 2010-03-16
- Inventor: David R. Liu , Joshua A. Bittker
- Applicant: David R. Liu , Joshua A. Bittker
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Fish & Richardson P.C.
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C12Q1/68 ; C07H21/02 ; C07H21/04 ; C07H21/00
Abstract:
Disclosed is a method of altering a nucleic acid. The method includes fragmenting a parent nucleic acid strand to generate nucleic acid fragments. At least a subset of the fragments are ligated to generate shuffled nucleic acid strands. A selected strand is identified from the shuffled nucleic acid strands for a criterion.
Public/Granted literature
- US20030027180A1 Nucleic acid shuffling Public/Granted day:2003-02-06
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