Invention Grant
- Patent Title: Process for the preparation of cyclosporin derivatives
- Patent Title (中): 环孢菌素衍生物的制备方法
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Application No.: US11797992Application Date: 2007-05-09
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Publication No.: US07678766B2Publication Date: 2010-03-16
- Inventor: Christian Viskov
- Applicant: Christian Viskov
- Applicant Address: FR Paris
- Assignee: Aventis Pharma S.A.
- Current Assignee: Aventis Pharma S.A.
- Current Assignee Address: FR Paris
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: FR9807846 19980622
- Main IPC: A61K38/13
- IPC: A61K38/13 ; C07K7/64
Abstract:
The invention concerns a novel method for preparing an intermediate polyanion for preparing cyclosporin derivatives by treating a cyclosporin with a hexamethyldisilazane metal salt, optionally in the presence of a metal halide. The treated cyclosporin has one or several free hydroxy groups and/or non-methylated nitrogen atoms in position α and/or any other acid group capable of deprotonation which are optionally deprotonated or in protected form.
Public/Granted literature
- US20070213260A1 Novel process for the preparation of cyclosporin derivatives Public/Granted day:2007-09-13
Information query
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