Invention Grant
US07678783B2 Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease
有权
用于治疗阿尔茨海默病的大环叔胺β-分泌酶抑制剂
- Patent Title: Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease
- Patent Title (中): 用于治疗阿尔茨海默病的大环叔胺β-分泌酶抑制剂
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Application No.: US11667913Application Date: 2005-11-14
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Publication No.: US07678783B2Publication Date: 2010-03-16
- Inventor: Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , Stacey Lindsley , Keith P. Moore , Shawn J. Stachel
- Applicant: Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , Stacey Lindsley , Keith P. Moore , Shawn J. Stachel
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent William Kronatin; John C. Todaro
- International Application: PCT/US2005/040984 WO 20051114
- International Announcement: WO2006/055434 WO 20060526
- Main IPC: A01N43/00
- IPC: A01N43/00 ; A61K31/33 ; C07D513/00
Abstract:
The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
Public/Granted literature
- US20080269302A1 Macrocyclic Tertiary Amine Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease Public/Granted day:2008-10-30
Information query
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