Invention Grant
US07678786B2 Benzoazepin-oxy-acetic acid derivatives as PPAR-delta agonists used for the increase of HDL-C, lower LDL-C and lower cholesterol
有权
用于增加HDL-C，较低LDL-C和较低胆固醇的苯并氮杂氧 - 乙酸衍生物作为PPAR-δ激动剂
- Patent Title: Benzoazepin-oxy-acetic acid derivatives as PPAR-delta agonists used for the increase of HDL-C, lower LDL-C and lower cholesterol
- Patent Title (中): 用于增加HDL-C，较低LDL-C和较低胆固醇的苯并氮杂氧 - 乙酸衍生物作为PPAR-δ激动剂
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Application No.: US11736221Application Date: 2007-04-17
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Publication No.: US07678786B2Publication Date: 2010-03-16
- Inventor: Gee-Hong Kuo , Yan Zhang , Lan Shen , Songfeng Lu , Keith T. Demarest , Patricia Pelton
- Applicant: Gee-Hong Kuo , Yan Zhang , Lan Shen , Songfeng Lu , Keith T. Demarest , Patricia Pelton
- Applicant Address: BE
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE
- Main IPC: A61P1/18
- IPC: A61P1/18 ; A61P3/06 ; A61P3/10 ; A61K31/55 ; C07D223/16
Abstract:
The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cataract, cardiovascular diseases, Metabolic X Syndrome, hyper-LDL-cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and hypo-HDL-cholesterolemia), atherosclerosis, obesity, and other disorders related to lipid metabolism and energy homeostasis complications thereof, using compounds of the invention are also described.
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