Invention Grant
US07678789B2 [1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular
有权
[1,2,4] - 二噻唑（di）ne衍生物，谷胱甘肽-S-转移酶和NADPH醌氧化还原酶的诱导剂，用于预防和治疗与一般细胞毒性有关的不利条件和特别是细胞凋亡
![[1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular](/docs/US/2010-03-16/US07678789B2/abs.jpg.600x600.jpg)
- Patent Title: [1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular
- Patent Title (中): [1,2,4] - 二噻唑（di）ne衍生物，谷胱甘肽-S-转移酶和NADPH醌氧化还原酶的诱导剂，用于预防和治疗与一般细胞毒性有关的不利条件和特别是细胞凋亡
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Application No.: US11349910Application Date: 2006-02-09
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Publication No.: US07678789B2Publication Date: 2010-03-16
- Inventor: Roelof W. Feenstra , Hiskias G. Keizer , Maria L. Pras-Raves , Bernard J Van Vliet , Gustaaf J. M. Van Scharrenburg
- Applicant: Roelof W. Feenstra , Hiskias G. Keizer , Maria L. Pras-Raves , Bernard J Van Vliet , Gustaaf J. M. Van Scharrenburg
- Applicant Address: NL Weesp
- Assignee: Solvay Pharmaceuticals B.V.
- Current Assignee: Solvay Pharmaceuticals B.V.
- Current Assignee Address: NL Weesp
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Main IPC: A61K31/541
- IPC: A61K31/541 ; A61K31/5377 ; A61K31/496 ; A61K31/4535 ; A61K31/4436 ; A61K31/41 ; C07D417/04 ; C07D413/04 ; C07D285/01
![[1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular](/abs-image/US/2010/03/16/US07678789B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidene-diamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein wherein the symbols have the meanings given in the specification.
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