Invention Grant
- Patent Title: Method for the enantiomoeric separation of optical active amlodipine
- Patent Title (中): 光学活性氨氯地平的对映体分离方法
-
Application No.: US10596209Application Date: 2004-12-03
-
Publication No.: US07678921B2Publication Date: 2010-03-16
- Inventor: Nanping Zhong , Xianfeng Zhao , Hui Ma , Yujie Chen
- Applicant: Nanping Zhong , Xianfeng Zhao , Hui Ma , Yujie Chen
- Applicant Address: CN
- Assignee: Shijiazhuang Pharmaceutical Group Ouyl Pharma. Co., Ltd.
- Current Assignee: Shijiazhuang Pharmaceutical Group Ouyl Pharma. Co., Ltd.
- Current Assignee Address: CN
- Agency: Fitch, Even, Tabin & Flannery
- Priority: CN200310119335 20031205
- International Application: PCT/CN2004/001412 WO 20041203
- International Announcement: WO2005/054196 WO 20050616
- Main IPC: C07D211/86
- IPC: C07D211/86
Abstract:
The present invention relates to the preparation of the (S)-(−)-amlodipine and (R)-(+)-amlodipine by means of enantiomeric separation of racemic amlodipine mixture, in which, L- or D-tartaric acid is used as resolution agent, and organic solvent containing 2-butanone is used as solvent. The 2-butanone used in the present invention has the advantage of low boiling point, low toxicity, litter pollution, and the method is suitable for large-scaled production.
Public/Granted literature
- US20070093661A1 Method for the enantiomoeric separation of optical active amlodipine Public/Granted day:2007-04-26
Information query
