A device for automatically disinfecting a portion of a medical implement, such as a needless hub or injection port. The device includes a body shaped to engage the medical implement with the portion to be disinfected exposed. A disinfectant pad is mounted on the body to permit displacement of the pad relative to the body and is biased such that when the pad is displaced from a rest position, the pad is urged toward the portion to be disinfected to contact and disinfect it.