Invention Grant
US07682601B2 Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes
失效
双官能三齿吡唑基含有重复和三正羰基络合物的配体
- Patent Title: Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes
- Patent Title (中): 双官能三齿吡唑基含有重复和三正羰基络合物的配体
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Application No.: US10551292Application Date: 2004-04-15
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Publication No.: US07682601B2Publication Date: 2010-03-23
- Inventor: Isabel Rego Santos , Joao Domingos Galamba Correia , Antonio Manuel Rocha Paulo , Susana Alves , Rute Vitor
- Applicant: Isabel Rego Santos , Joao Domingos Galamba Correia , Antonio Manuel Rocha Paulo , Susana Alves , Rute Vitor
- Applicant Address: US MO Hazelwood
- Assignee: Mallinckrodt Inc.
- Current Assignee: Mallinckrodt Inc.
- Current Assignee Address: US MO Hazelwood
- Priority: EP03076106 20030415; EP03078217 20031010
- International Application: PCT/US2004/011685 WO 20040415
- International Announcement: WO2004/091669 WO 20041028
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14
Abstract:
The present invention relates to a chelating agent of the general formula: (I), wherein m is 0 or 1; X is NR4 or S; Y is SR5, NHR5 or P(R5)2; R1 and R3 are the same or different and are selected from H, alkyl or aryl; R2 is H, COOH, NHR6 or (CH2)nCOOR6; R4 is H, alkyl, aryl, (CH2)nCOOR6 or (CH2)nOR6; R5 is H, alkyl, aryl, (CH2)nCOOR6 or (CH2)nOR6, R6 is H, alkyl or aryl; n is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; and when R1═R3═CH3, R2, R4 and R5 are not all three H. The invention further relates to a method and kit for the preparation of radiolabeled biomolecules while using the chelating agent.
Public/Granted literature
- US20060198785A1 Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes Public/Granted day:2006-09-07
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