Invention Grant
- Patent Title: Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier
- Patent Title (中): 用于运输物质穿过血脑屏障的人造低密度脂蛋白载体
-
Application No.: US11648808Application Date: 2007-01-03
-
Publication No.: US07682627B2Publication Date: 2010-03-23
- Inventor: Thomas Nelson , Alessandro Quattrone , Daniel Alkon
- Applicant: Thomas Nelson , Alessandro Quattrone , Daniel Alkon
- Applicant Address: US WV Morgantown
- Assignee: Blanchette Rockefeller Neurosciences Institute
- Current Assignee: Blanchette Rockefeller Neurosciences Institute
- Current Assignee Address: US WV Morgantown
- Agency: Milbank, Tweed, Hadley & McCloy, LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K31/58 ; A61K39/395 ; A61K39/00 ; A61K9/127 ; A61K9/50
Abstract:
This invention relates to a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery therapeutic agents across the blood-brain barrier (BBB). In particular, this invention relates to artificial LDL particles comprised of three lipid elements: phosphatidyl choline, fatty-acyl-cholesterol esters, and at least one apolipoprotein. The present invention further relates to compositions, methods and kits comprising artificial LDL particles for targeting drugs to and across the BBB for the prevention and treatment of brain diseases.
Public/Granted literature
- US20070134313A1 Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier Public/Granted day:2007-06-14
Information query
IPC分类:
