Invention Grant
US07682807B2 Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation
有权
基于丝裂原活化蛋白激酶磷酸化的阿尔茨海默病诊断
- Patent Title: Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation
- Patent Title (中): 基于丝裂原活化蛋白激酶磷酸化的阿尔茨海默病诊断
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Application No.: US10469164Application Date: 2002-02-27
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Publication No.: US07682807B2Publication Date: 2010-03-23
- Inventor: Wei-Qin Zhao , Daniel L. Alkon
- Applicant: Wei-Qin Zhao , Daniel L. Alkon
- Applicant Address: US WI Morgantown
- Assignee: Blanchette Rockefeller Neurosciences Institute
- Current Assignee: Blanchette Rockefeller Neurosciences Institute
- Current Assignee Address: US WI Morgantown
- Agency: Milbank, Tweed, Hadley & McCloy, LLP
- International Application: PCT/US02/05672 WO 20020227
- International Announcement: WO02/067764 WO 20020906
- Main IPC: G01N33/567
- IPC: G01N33/567 ; C12Q1/00 ; G01N33/00
Abstract:
A method of diagnosing Alzheimer's disease in a patient comprises determining whether the phosphorylation level of an indicator protein in cells of the patient after stimulus with an activator compound is abnormally elevated as compared to a basal phosphorylation level, the indicator protein being e.g. Erk1/2 and the activator compound being e.g. bradykinin.
Public/Granted literature
- US20050059092A1 Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation Public/Granted day:2005-03-17
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