Invention Grant
US07683033B2 Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
失效
丝氨酸蛋白酶抑制剂，特别是HCV NS3-NS4A蛋白酶
- Patent Title: Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
- Patent Title (中): 丝氨酸蛋白酶抑制剂，特别是HCV NS3-NS4A蛋白酶
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Application No.: US11051977Application Date: 2005-02-04
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Publication No.: US07683033B2Publication Date: 2010-03-23
- Inventor: Kevin M. Cottrell , John J. Court , David D. Deininger , Luc J. Farmer , Janos Pitlik , Robert B. Permi
- Applicant: Kevin M. Cottrell , John J. Court , David D. Deininger , Luc J. Farmer , Janos Pitlik , Robert B. Permi
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agent Susan C. Kelly
- Main IPC: A61K38/07
- IPC: A61K38/07 ; A61K39/42
Abstract:
The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
Public/Granted literature
- US20050215486A1 Inhibitors of serine proteases, particularly HCV NS3-NS4A protease Public/Granted day:2005-09-29
Information query
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