Invention Grant
US07683080B2 Stable iansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
失效
含有超过500ppm，高达约3,000ppm水和超过200ppm，高达约5,000ppm酒精的稳定的索非唑
- Patent Title: Stable iansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
- Patent Title (中): 含有超过500ppm，高达约3,000ppm水和超过200ppm，高达约5,000ppm酒精的稳定的索非唑
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Application No.: US10717325Application Date: 2003-11-18
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Publication No.: US07683080B2Publication Date: 2010-03-23
- Inventor: Anita Liberman , Claude Singer , Irena Veinberg
- Applicant: Anita Liberman , Claude Singer , Irena Veinberg
- Applicant Address: IL Petah Tiqva
- Assignee: Teva Pharmaceutical Industries Ltd.
- Current Assignee: Teva Pharmaceutical Industries Ltd.
- Current Assignee Address: IL Petah Tiqva
- Agency: Kenyon & Kenyon LLP
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; C07D401/12
Abstract:
The present invention provides a stable 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazole (lansoprazole) comprising either greater than 500 ppm and not more than about 3,000 ppm water or greater than 200 ppm and not more than about 5,000 ppm alcohol, or both. The present invention provides a method of preparing a stable lansoprozole as well as a pharmaceutical composition containing same. The present invention further provides a method of purifying lansoprazole that is substantially free of sulfone and sulfide derivatives.
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