Invention Grant
US07683087B2 N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl] -p-amino benzoic acids as HIV reverse transcriptase inhibitors
有权
作为HIV逆转录酶抑制剂的N [S（4-芳基 - 三唑-3-基）α-巯基乙酰基] - 对氨基苯甲酸
![N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl] -p-amino benzoic acids as HIV reverse transcriptase inhibitors](/docs/US/2010-03-23/US07683087B2/abs.jpg.600x600.jpg)
- Patent Title: N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl] -p-amino benzoic acids as HIV reverse transcriptase inhibitors
- Patent Title (中): 作为HIV逆转录酶抑制剂的N [S（4-芳基 - 三唑-3-基）α-巯基乙酰基] - 对氨基苯甲酸
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Application No.: US12193599Application Date: 2008-08-18
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Publication No.: US07683087B2Publication Date: 2010-03-23
- Inventor: Jean-Luc Girardet , Martha de la Rosa , Zhi Hong , Stanley Lang
- Applicant: Jean-Luc Girardet , Martha de la Rosa , Zhi Hong , Stanley Lang
- Applicant Address: US CA San Diego
- Assignee: Ardea Biosciences, Inc.
- Current Assignee: Ardea Biosciences, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Wilson Sonsini Goodrich & Rosati
- Main IPC: A61K31/4196
- IPC: A61K31/4196 ; C07D249/08
![N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl] -p-amino benzoic acids as HIV reverse transcriptase inhibitors](/abs-image/US/2010/03/23/US07683087B2/abs.jpg.150x150.jpg)
Abstract:
A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
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