Invention Grant
- Patent Title: Process for the preparation of Rivastigmine
- Patent Title (中): 制备瑞斯的明的方法
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Application No.: US11590566Application Date: 2006-10-31
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Publication No.: US07683205B2Publication Date: 2010-03-23
- Inventor: Pandurang Balwant Deshpande , Kishore Khemani , Bharat Becharbhai Boda , Tushar Rajnikant Shah , Hitarth Harshendu Acharya , Parven Kumar Luthra
- Applicant: Pandurang Balwant Deshpande , Kishore Khemani , Bharat Becharbhai Boda , Tushar Rajnikant Shah , Hitarth Harshendu Acharya , Parven Kumar Luthra
- Applicant Address: IN Gujarat
- Assignee: Alembic Limited
- Current Assignee: Alembic Limited
- Current Assignee Address: IN Gujarat
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: IN1290/MUM/2006 20060817
- Main IPC: C07C271/40
- IPC: C07C271/40 ; C07C215/46
Abstract:
The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1=R2=H or R1=H and R2=CH3 or an acid addition salt thereof, using paraformaldehyde in the presence of Raney Nickel and hydrogen in a suitable solvent to obtain compound of formula (II).
Public/Granted literature
- US20080045743A1 Process for the preparation of Rivastigmine Public/Granted day:2008-02-21
Information query
