Invention Grant
US07687233B2 Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin K epoxide reductase gene and warfarin dosage
有权
维生素K环氧化物还原酶基因单核苷酸多态性与华法林用量相关的方法和组成
- Patent Title: Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin K epoxide reductase gene and warfarin dosage
- Patent Title (中): 维生素K环氧化物还原酶基因单核苷酸多态性与华法林用量相关的方法和组成
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Application No.: US10573131Application Date: 2004-09-23
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Publication No.: US07687233B2Publication Date: 2010-03-30
- Inventor: Darrel W. Stafford , Tao Li
- Applicant: Darrel W. Stafford , Tao Li
- Applicant Address: US NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Myers Bigel Sibley & Sajovec, P.A.
- International Application: PCT/US2004/031481 WO 20040923
- International Announcement: WO2005/030039 WO 20050407
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; C07H21/02 ; C07H21/04
Abstract:
The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying the subject having increased or decreased sensitivity to warfarin.
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