Invention Grant
US07687241B2 Methods and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof
有权
用于分离转移性癌细胞的方法和组合物，以及用于测量其癌症的转移潜力
- Patent Title: Methods and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof
- Patent Title (中): 用于分离转移性癌细胞的方法和组合物，以及用于测量其癌症的转移潜力
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Application No.: US11010122Application Date: 2004-12-10
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Publication No.: US07687241B2Publication Date: 2010-03-30
- Inventor: Wen-Tien Chen
- Applicant: Wen-Tien Chen
- Applicant Address: US NY Albany
- Assignee: The Research Foundation of State University of New York
- Current Assignee: The Research Foundation of State University of New York
- Current Assignee Address: US NY Albany
- Agency: Hoffmann & Baron, LLP
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; G01N33/53 ; G01N33/567 ; G01N33/574 ; C02F1/26 ; C02F1/44 ; B01D11/00 ; B01D15/08
Abstract:
The present invention relates to novel methods and compositions for detection and isolation of cancer cells with metastatic potential. The invention further relates to assays for measuring the metastatic potential of such cancer cells and drug screening assays for the identification of agents having anti-metastatic potential. The present invention further provides methods and compositions for inhibiting the metastatic potential of cancer cells by modulating the activity of serine integral membrane proteases [(SIMP) consisting of seprase and dipetidyl peptidase IV (DPPIV)] expressed on the surface of metastasizing cancer cells.
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