Invention Grant
- Patent Title: Pyridothienopyridazinone derivatives as mGluR1 antagonists
- Patent Title (中): 吡啶并噻吩并哒嗪酮衍生物作为mGluR1拮抗剂
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Application No.: US11505140Application Date: 2006-08-16
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Publication No.: US07687501B2Publication Date: 2010-03-30
- Inventor: Chad E. Bennett , William J. Greenlee , Chad E. Knutson , Duane A. Burnett
- Applicant: Chad E. Bennett , William J. Greenlee , Chad E. Knutson , Duane A. Burnett
- Applicant Address: US NJ Kenilworth
- Assignee: Schering Corporation
- Current Assignee: Schering Corporation
- Current Assignee Address: US NJ Kenilworth
- Agent Krishna G. Bannerjee; Kenrick L. Vidale; Keith D. MacMillan
- Main IPC: C07D495/14
- IPC: C07D495/14 ; C07D417/14 ; A61K31/4985 ; C07D213/85 ; C07D495/04 ; C07D239/30 ; C07D239/58 ; A61P25/06 ; A61P25/04 ; A61P25/22 ; A61P25/28

Abstract:
In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J3, X, Z, and R1, R3, and R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.
Public/Granted literature
- US20070072864A1 Fused tricyclic mGIuR1 antagonists as therapeutic agents Public/Granted day:2007-03-29
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