Invention Grant
US07687501B2 Pyridothienopyridazinone derivatives as mGluR1 antagonists 失效
吡啶并噻吩并哒嗪酮衍生物作为mGluR1拮抗剂

Pyridothienopyridazinone derivatives as mGluR1 antagonists
Abstract:
In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J3, X, Z, and R1, R3, and R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.
Public/Granted literature
Information query
Patent Agency Ranking
0/0