Invention Grant
US07687628B2 Method of preparing 4-amino-1H-imidazo(4,5-c)quinolines and acid addition salts thereof
有权
4-氨基-1H-咪唑并（4,5-c）喹啉及其酸加成盐的制备方法
- Patent Title: Method of preparing 4-amino-1H-imidazo(4,5-c)quinolines and acid addition salts thereof
- Patent Title (中): 4-氨基-1H-咪唑并（4,5-c）喹啉及其酸加成盐的制备方法
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Application No.: US10956465Application Date: 2004-09-30
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Publication No.: US07687628B2Publication Date: 2010-03-30
- Inventor: Daniella Gutman , Wael Baidossi , Shimon Chernyak
- Applicant: Daniella Gutman , Wael Baidossi , Shimon Chernyak
- Applicant Address: US NY Hawthorne
- Assignee: Taro Pharmaceuticals U.S.A., Inc.
- Current Assignee: Taro Pharmaceuticals U.S.A., Inc.
- Current Assignee Address: US NY Hawthorne
- Agency: Venable LLP
- Agent Lars H. Genieser; Zayd Alathari
- Main IPC: C07D491/06
- IPC: C07D491/06 ; A61K31/44
Abstract:
The present invention provides a method of preparing a 4-(arylmethyl)amino-1H-imidazo(4,5-c)quinoline of formula (4) by reacting an arylmethylamine of formula (3) with a 4-chloro-1H-imidazo(4,5-c)quinoline of formula (2). The present invention further provides a method of preparing an acid addition salt of formula (5) comprising the step of hydrolyzing a 4-(arylmethyl)amino-1H-imidazo(4,5-c)quinoline of formula (4) with a strong acid, HX. The present invention further provides a method of preparing a 4-amino-1H-imidazo(4,5-c)quinoline of formula (1) comprising the step of treating an acid addition salt of formula (5) with a base.
Public/Granted literature
- US20050085500A1 Method of preparing 4-amino-1H- imidazo(4,5-c)quinolines and acid addition salts thereof Public/Granted day:2005-04-21
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