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US07687651B2 Method for the preparation of trans-or cis-diammoniumdichlorodihydroxoplatinum(IV) and the use thereof in the production of pharmaceutical active substances 失效
制备反式或顺式二氯二羟基喹啉（IV）的方法及其在制备药物活性物质中的应用

  • Patent Title: Method for the preparation of trans-or cis-diammoniumdichlorodihydroxoplatinum(IV) and the use thereof in the production of pharmaceutical active substances
  • Patent Title (中): 制备反式或顺式二氯二羟基喹啉（IV）的方法及其在制备药物活性物质中的应用
  • Application No.: US10595400
    Application Date: 2004-10-13
  • Publication No.: US07687651B2
    Publication Date: 2010-03-30
  • Inventor: Zoser B. Salama
  • Applicant: Zoser B. Salama
  • Applicant Address: DE
  • Assignee: RIEMSER Arzneimittel AG
  • Current Assignee: RIEMSER Arzneimittel AG
  • Current Assignee Address: DE
  • Agency: Pequignot & Myers LLC
  • Agent Joyce von Natzmer
  • Priority: EP03090344 20031013
  • International Application: PCT/DE2004/002296 WO 20041013
  • International Announcement: WO2005/040045 WO 20050506
  • Main IPC: C07F15/00
  • IPC: C07F15/00 ;  A61K31/28 ;  A61K33/24
Method for the preparation of trans-or cis-diammoniumdichlorodihydroxoplatinum(IV) and the use thereof in the production of pharmaceutical active substances
Abstract:
The invention relates to a method for the preparation of trans- or cis-diammoniumdichlorodihydroxoplatinum(IV) and derivatives thereof. What is suggested is reacting trans- or cis-diammoniumdichloroplatinum(II) with a solution comprising >30% peroxide at temperatures below 30° C. and dissolving the product thus obtained in a mineral acid and subsequently precipitating with an alkaline solution.
Abstract(Chinese):

本发明涉及一种制备反式或顺式二铵二氯二羟基铂（IV）及其衍生物的方法。 反应或顺式二铵二氯铂（II）与温度低于30℃的含30％过氧化物的溶液反应，并将所得产物溶于无机酸中，随后用碱性溶液沉淀。

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