A variable-gain wide-dynamic-range amplifier including an amplifier module, a control unit, and an output current regulating circuit is provided. The amplifier module amplifies an input signal. The amplifier module includes several amplifier units coupled to each other in parallel. The gains of the amplifier units are different. The control unit enables at least one of the amplifier units according to a gain control signal. The at least one of the amplifier units which is enabled is for outputting a current signal in response to the input signal. The output regulating circuit is for receiving the current signal and outputting an output signal accordingly by regulating the magnitude of the current signal under the control of the control unit. Each of the amplifier units is coupled to the output current regulating circuit in series. The control unit is for controlling the output current regulating circuit according to the gain control signal.