A method and system to use floating differential output amplifiers wired in series and parallel to achieve arbitrary output drive voltage and current for the applications load. One embodiment includes the use of multiple differential amplifiers wired in series to generate a high voltage differential amplifier, while only partially using no-feedback buffer amplifiers and obtaining performance equivalent to an implementation that uses only buffer amplifiers. This is achieved by forcing the mismatch errors of conventional amplifiers to become power supply ripple. A second embodiment includes the use of a power supply centering technique to implement a floating asymmetrical differential amplifier. A third embodiment includes the use of multiple floating differential amplifiers, sharing a common power supply with individual biasing and isolation of each section of the amplifier, to allow high power amplifiers to be built with an arbitrary number of low power modules.