An interference-rejection coding method for an optical wireless communication system and such an optical wireless communication system are provided. The coding method uses delay modulation, block code techniques and filtering to reduce the low frequency interference from light sources. A plurality of codewords from the block codes are reserved for performing digital data recovery. The invention removes the need of analog clock data recovery circuit, and does not require complex hardware for realization. Therefore, it can be applied to a wide range of applications, such as optical WLAN, data transmission of medical facilities, wireless communication in the aircraft, encrypted data transmission network, and low-priced transmission interfaces.