The present invention relates to an automatic medicine packing machine for packing a variety of medicines dose by dose continuously. According to one embodiment, there is provided an automatic medicine packing machine for packing a variety of medicines dose by dose continuously, including: a plurality of cassette units in which the variety of medicines are accommodated; a hopper for collecting the medicines discharged from the cassette units; a packing unit for packing the medicines collected by the hopper; and a shutter assembly mounted on the hopper to temporarily suspend the medicines discharged from the cassette units, wherein the shutter assembly includes a frame detachably mounted to an upper end of the hopper; an openable/closable shutter unit arranged and mounted on the frame; a driving means for driving the shutter unit to be opened and closed; and an interlocking unit for transferring a driving force of the driving means to the shutter unit to interlock the shutter unit.