A catheter device and related method for diagnostic vascular treatment and/or therapeutic vascular treatment of a subject's vasculature having a lesion. The device including: a guide catheter comprising a shaft having a proximal portion and a distal portion; a guide wire disposed in the guide catheter shaft having a proximal portion and a distal portion, the guide wire transfers beyond the lesion during at least a portion of the vascular treatment and/or therapeutic vascular treatment; and one or more expandable component disposed at the distal portion of the guide wire. The expandable component(s) may be positioned distally beyond the lesion during at least a portion of the vascular treatment and/or therapeutic vascular treatment. The expandable component(s) being used to: anchor said guide wire to mitigate and/or prevent loss of guide wire position during at least a portion of the vascular treatment and/or therapeutic vascular treatment; and avoid and/or mitigate trauma to the vasculature during at least a portion of the vascular treatment and/or therapeutic vascular treatment.