Invention Grant
US07691393B2 Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the Listeria, and methods of use thereof
有权
利斯特氏菌减弱以进入非吞噬细胞，包含利斯特氏菌的疫苗及其使用方法
- Patent Title: Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the Listeria, and methods of use thereof
- Patent Title (中): 利斯特氏菌减弱以进入非吞噬细胞，包含利斯特氏菌的疫苗及其使用方法
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Application No.: US10773792Application Date: 2004-02-06
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Publication No.: US07691393B2Publication Date: 2010-04-06
- Inventor: Thomas W. Dubensky, Jr. , Dirk G. Brockstedt , David N. Cook
- Applicant: Thomas W. Dubensky, Jr. , Dirk G. Brockstedt , David N. Cook
- Applicant Address: US CA Concord
- Assignee: Anza Therapeutics, Inc.
- Current Assignee: Anza Therapeutics, Inc.
- Current Assignee Address: US CA Concord
- Agency: BioTechnology Law Group
- Agent Michael A. Whittaker
- Main IPC: A61K39/02
- IPC: A61K39/02
Abstract:
The present invention provides Listeria that are attenuated for entry into non-phagocytic cells as well as a variety of methods of inducing immune responses involving administering compositions comprising the attenuated Listeria. Some of the attenuated Listeria are mutant Listeria that comprise at least one mutation in a gene encoding an invasin, such as an internalin. Some of the attenuated Listeria are further attenuated for cell-to-cell spread. Pharmaceutical compositions and vaccines useful in the methods of the invention are further provided. Methods of making and improving vaccines are also provided.
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