Invention Grant
US07691632B2 Kit for detecting the level of cyclin-dependent kinase inhibitor P16 gene expression
失效
用于检测细胞周期蛋白依赖性激酶抑制剂P16基因表达水平的试剂盒
- Patent Title: Kit for detecting the level of cyclin-dependent kinase inhibitor P16 gene expression
- Patent Title (中): 用于检测细胞周期蛋白依赖性激酶抑制剂P16基因表达水平的试剂盒
-
Application No.: US12195135Application Date: 2008-08-20
-
Publication No.: US07691632B2Publication Date: 2010-04-06
- Inventor: David H. Beach , Douglas J. Demetrick , Manuel Serrano , Gregory J. Hannon
- Applicant: David H. Beach , Douglas J. Demetrick , Manuel Serrano , Gregory J. Hannon
- Applicant Address: US NY Cold Spring Harbor
- Assignee: Cold Spring Harbor Laboratory
- Current Assignee: Cold Spring Harbor Laboratory
- Current Assignee Address: US NY Cold Spring Harbor
- Agency: Howrey LLP
- Agent Viola T. Kung
- Main IPC: C07K16/00
- IPC: C07K16/00
Abstract:
The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a family of cell-cycle regulatory proteins (“CCR-proteins”). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. The present invention comprises antibodies directed to such CCR-proteins. The present invention is directed to a kit for detecting the level of cyclin-dependent kinase inhibitor p16 gene expression comprising antibodies directed to a p16 protein.
Public/Granted literature
- US20090170098A1 ANTIBODIES TO CELL-CYCLE REGULATORY PROTEIN P16, AND USES RELATED THERETO Public/Granted day:2009-07-02
Information query
