Invention Grant
US07691824B2 Compositions and methods for inhibiting expression of a gene from the JC virus
失效
用于抑制基因从JC病毒表达的组合物和方法
- Patent Title: Compositions and methods for inhibiting expression of a gene from the JC virus
- Patent Title (中): 用于抑制基因从JC病毒表达的组合物和方法
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Application No.: US11741205Application Date: 2007-04-27
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Publication No.: US07691824B2Publication Date: 2010-04-06
- Inventor: Pamela Tan , Dinah Sah , Birgit Bramlage
- Applicant: Pamela Tan , Dinah Sah , Birgit Bramlage
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Fenwick & West LLP
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04 ; C12N21/00 ; C12N15/00 ; C12N5/00
Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.
Public/Granted literature
- US20090062225A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE JC VIRUS Public/Granted day:2009-03-05
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