Invention Grant
- Patent Title: N-hydroxyamide derivatives possessing antibacterial activity
- Patent Title (中): 具有抗菌活性的N-羟基酰胺衍生物
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Application No.: US10617616Application Date: 2003-07-11
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Publication No.: US07691843B2Publication Date: 2010-04-06
- Inventor: Bore G. Raju , Hardwin O'Dowd , Hongwu Gao , Dinesh V. Patel , Jaoquim Trias
- Applicant: Bore G. Raju , Hardwin O'Dowd , Hongwu Gao , Dinesh V. Patel , Jaoquim Trias
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent Gregg C. Benson; Michael Dixon; Jason Tebbutt
- Main IPC: A61K31/397
- IPC: A61K31/397 ; C07D205/00
Abstract:
Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.
Public/Granted literature
- US20080058304A1 N-hydroxyamide derivatives possessing antibacterial activity Public/Granted day:2008-03-06
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