Invention Grant
US07691881B2 1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-HT4 receptor agonistic activity
失效
具有5-HT 4受体激动活性的1-异丙基-2-氧代-1,2-二氢吡啶-3-甲酰胺衍生物
- Patent Title: 1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-HT4 receptor agonistic activity
- Patent Title (中): 具有5-HT 4受体激动活性的1-异丙基-2-氧代-1,2-二氢吡啶-3-甲酰胺衍生物
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Application No.: US10597480Application Date: 2005-01-18
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Publication No.: US07691881B2Publication Date: 2010-04-06
- Inventor: Tomoki Kato , Kiyoshi Kawamura , Chikara Uchida
- Applicant: Tomoki Kato , Kiyoshi Kawamura , Chikara Uchida
- Applicant Address: US NY New York
- Assignee: Pfizer Inc
- Current Assignee: Pfizer Inc
- Current Assignee Address: US NY New York
- Agent Gregg C. Benson; James T. Jones
- International Application: PCT/IB2005/000173 WO 20050118
- International Announcement: WO2005/073222 WO 20050811
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D401/12

Abstract:
This invention provides a compound of formula (I): wherein R1 represents an alkyl group having from 1 to 4 carbon atoms or a halogen atom, R2 represents an alkyl group having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or a hydroxy group, and A represents an oxygen atom or a group of the formula —C(R4)(R5)— (in which R4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R5 represents a hydroxy group or an alkoxy group having from 1 to 4 carbon atoms) or a pharmaceutically acceptable salts thereof. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.
Public/Granted literature
- US20080293767A1 1-Isopropyl-2-Oxo-1,2-Dihydropyridine-3-Carboxamide Derivatives Having 5-Ht4 Receptor Agonistic Activity Public/Granted day:2008-11-27
Information query
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