Invention Grant
US07691881B2 1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-HT4 receptor agonistic activity 失效
具有5-HT 4受体激动活性的1-异丙基-2-氧代-1,2-二氢吡啶-3-甲酰胺衍生物

  • Patent Title: 1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-HT4 receptor agonistic activity
  • Patent Title (中): 具有5-HT 4受体激动活性的1-异丙基-2-氧代-1,2-二氢吡啶-3-甲酰胺衍生物
  • Application No.: US10597480
    Application Date: 2005-01-18
  • Publication No.: US07691881B2
    Publication Date: 2010-04-06
  • Inventor: Tomoki KatoKiyoshi KawamuraChikara Uchida
  • Applicant: Tomoki KatoKiyoshi KawamuraChikara Uchida
  • Applicant Address: US NY New York
  • Assignee: Pfizer Inc
  • Current Assignee: Pfizer Inc
  • Current Assignee Address: US NY New York
  • Agent Gregg C. Benson; James T. Jones
  • International Application: PCT/IB2005/000173 WO 20050118
  • International Announcement: WO2005/073222 WO 20050811
  • Main IPC: A61K31/445
  • IPC: A61K31/445 C07D401/12
1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-HT4 receptor agonistic activity
Abstract:
This invention provides a compound of formula (I): wherein R1 represents an alkyl group having from 1 to 4 carbon atoms or a halogen atom, R2 represents an alkyl group having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or a hydroxy group, and A represents an oxygen atom or a group of the formula —C(R4)(R5)— (in which R4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R5 represents a hydroxy group or an alkoxy group having from 1 to 4 carbon atoms) or a pharmaceutically acceptable salts thereof. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.
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