Invention Grant
US07691900B2 Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics
失效
具有长羟基化链的生育酚衍生物,可用作神经营养
- Patent Title: Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics
- Patent Title (中): 具有长羟基化链的生育酚衍生物,可用作神经营养
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Application No.: US10572933Application Date: 2004-09-24
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Publication No.: US07691900B2Publication Date: 2010-04-06
- Inventor: Bang Luu , Paul Heuschling , Thierry Muller , Eleonora Morga
- Applicant: Bang Luu , Paul Heuschling , Thierry Muller , Eleonora Morga
- Applicant Address: LU Luxembourg
- Assignee: AxoGlia Therapeutics S.A.
- Current Assignee: AxoGlia Therapeutics S.A.
- Current Assignee Address: LU Luxembourg
- Agency: The Nath Law Group
- Priority: FR0311325 20030926
- International Application: PCT/FR2004/002424 WO 20040924
- International Announcement: WO2005/030748 WO 20050407
- Main IPC: A01N43/02
- IPC: A01N43/02 ; A01N43/16 ; A61K31/335 ; A61K31/35

Abstract:
The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia an/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula.
Public/Granted literature
- US20070105946A1 Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics Public/Granted day:2007-05-10
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